Dra. Lorenza González Mariscal

Investigador Cinvestav 3E
SNII Nivel III Investigadora Emérita

  • Licenciatura en Biología Experimental (1980). UAM-I 
  • Maestría en Biología Experimental (1984). UAM-I
  • Doctorado en Ciencias (1988).  Depto. de Fisiología, Biofísica y Neurociencias. CINVESTAV.
Sitio Web Institucional:
https://www.cinvestav.mx/zacatenco/fisiologia/conocimiento/directorio-de-investigacion/lorenza-gonzalez-mariscal
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Email

lorenza@cinvestav.mx
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Teléfono

(+52) 55 5747 3800 +3966

Del Oso Agustín Erika Yedid

Asistente Secretarial
erika.deloso@cinvestav.mx
(+52) 55 5747 3800 +5182
Línea de Investigación:

El laboratorio  de la Dra Lorenza González-Mariscal se especializa en el estudio de los epitelios y en particular en una estructura de adhesión célula-célula denominada Unión Estrecha (UE). Explora el papel de  la proteína ZO-2 en la formación y el sellado de la UE, analiza cómo ZO-2 afecta la proliferación y el tamaño celular. Ya que su laboratorio encontró que ZO-2 también está presente en el núcleo y los centrosomas, estudia cómo ZO-2 entra y sale del núcleo, su efecto en la transcripción génica y en la formación de cilios y el huso mitótico. Las UEs son la base de las  barreras hemato-encefálica,  hemato-testicular y hemato-placentaria, por ello en su laboratorio se estudian mecanismos de regulación de estas barreras y su respuesta a condiciones patológicas y el contacto con pesticidas y virus.

ZO-2 is a scaffold at the centriole and mitotic spindle poles that enhances microtubule stability and supports the proper development of mitotic spindles and cilia

Vega-Torreblanca, S., Pinto-Dueñas, D.C., Hernández-Guzmán, C., Martín-Tapia, D., Alarcón, L., Chávez-Munguía, B., Salazar-Villatoro, L., González-Pozos, S.,  Josué David Hernández-Varela,  J.D., Ramírez-Martínez, L., López-Bayghen, E., Chanona-Pérez, J.J., and González-Mariscal, L.
Cell and Tissue Research (2025). https://doi.org/10.1007/s00441-025-03992-0

Preserving blood-brain barrier integrity in ischemic stroke: a review on MSCs-sEVs content and potential molecular targets.

Lozano-Lopez, D. A., Hernández-Ortega L.D., González-Mariscal, L., Díaz-Coránguez, M., Pinto-Dueñas, D.C., and Castañeda-Arellano, R.
Molecular Neurobiology (2025)  https://doi.org/10.1007/s12035-025-04956-9.

A copper-binding peptide with therapeutical potential against Alzheimer’s disease: From the blood-brain barrier to the fight for copper.

Lopez-Guerrero, V. E., Posadas, Y., Sánchez-López, C., Smart, S., Miranda, J., Singewald, K., Bandala, Y., Nachtegaal, M., Juaristi, E., Den Auwer, C., Pérez-Cruz, C., González-Mariscal, L., Millhauser, G., Segovia, J., Quintanar, L.
ACS Chemical Neuroscience, (2025) 16:241-261. https://doi.org/10.1021/acschemneuro.4c00796

A short guide to the tight junction

Citi, S., Fromm, M., Furuse, M., González-Mariscal, L., Nusrat, A., Tsukita, S., and Turner, J. 
J. Cell Sci. (2024) 137:261776. https://doi.org/10.1242/jcs.261776

The role of ZO-2 in modulating JAM-A and -actin junctional recruitment, apical membrane and tight junction tension, and cell response to substrate stiffness and topography

Gallego-Gutiérrez, H., González- González, L., Ramírez-Martínez, L., López-Bayghen, E., and González-Mariscal, L.
Mol. Biol. Cell.  (2021) 32:1347-1358

Polyubiquitination and SUMOylation sites regulate the stability of ZO-2 protein and the sealing of tight junctions

Cano-Cortina, M., Alarcón, L., Miranda, J., Huber, O. and González-Mariscal, L.
Cells (2022) 11:3296. https://doi.org/10.3390/cells11203296

Editorial: Investigating the factors that control epithelial cell polarity and adhesion during morphogenesis

González-Mariscal, L.
Frontiers in Cell and Developmental Biology, (2021) 9:802568.

ZO-2 favors Hippo signaling, and its re-expression in the steatotic liver by AMPK restores junctional sealing

González-González, L., Gallego-Gutiérrez, H., Martin-Tapia, D., Avelino-Cruz, J. E., Hernández-Guzmán, C., Rangel-Guerrero, S. I., Alvarez-Salas, L. M., Garay, E., Chávez-Munguía, B.,  Gutiérrez-Ruiz, M. C., Hernández-Melchor, D., López-Bayghen, E., and González-Mariscal,  L.
Tissue Barriers (2021) e1994351-21.

Zonula occludens 2 and cell-cell contacts are required for normal nuclear shape in epithelia

Hernández-Guzmán, C., Gallego-Gutiérrez, H., Chávez-Munguía, B., Martín-Tapia, D., and González-Mariscal, L.
Cells (2021) 10:2658.

Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD

Gallego-Gutiérrez, H., González- González, L., Ramírez-Martínez, L., López-Bayghen, E., and González-Mariscal, L.
Mol. Biol. Cell.  (2021) 32:1347-1358

Molecular insights into the thrombotic and microvascular injury in placental endothelium of women with mild or severe COVID-19

Flores-Pliego, A., Miranda, J., Vega-Torreblanca, S., Valdespino-Vázquez, Y., Helguera-Repetto, C., Espejel-Nuñez, A., Borboa-Olivares, H., Espino y Sosa, S., Mateu-Rogell, P., León-Juárez, M., Ramírez-Santes, V., Cardona-Pérez, A., Villegas-Mota, I., Torres-Torres, J., Juárez-Reyes, A., Rizo-Pica, T., González, R.O., González-Mariscal, L., and Estrada-Gutierrez, G.
Cells (2021) 10:364

E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions

Uc, P.Y., Miranda, J., Raya-Sandino, A., Alarcón, L., Roldán, M.L., Ocadiz-Delgado, R., Cortés-Malagón, E.M., Chávez-Munguía, B., Ramírez, G., Asomoza, R., Shoshani, L., Gariglio, P., and González-Mariscal, L.
Int. J. Oncology (2020) 57:905-924

Relationship between apical junction proteins, gene expression and cancer

Gonzalez-Mariscal, L., Miranda, J., Gallego-Gutiérrez, H., Cano-Cortina, M. and Amaya, E.
Biochim. Biophys. Acta Biomembr. (2020) 1862:183278

Methyl parathion causes genetic damage in sperm and disrupts the permeability of the blood-testis barrier by an oxidant mechanism in mice

Uriosteguí-Acosta, M., Tello-Mora, P., Solís-Heredia, M.J., Ortega-Olvera,  Piña-Guzmán, B-. Martín-Tapia, D., Gonzalez-Mariscal, L., and Quintanilla-Vega, B.
Toxicology (2020) 438:152463

Syncytiotrophoblast of placentae from women with Zika virus infection has altered tight junction protein expression and increased paracellular permeability

Miranda, J., Martín-Tapia, D., Valdespino-Vázquez, Y., Alarcón, L., Espejel-Nuñez, A., Guzmán-Huerta, M., Muñoz-Medina J. E., Shibayama, M., Chávez-Mungía, B., Estrada-Gutiérrez, G., Lievano, S., Ludert, J. E., and González-Mariscal, L.
Cells (2019) 8:1174.

ZO-2 is a master regulator of gene expression, cell proliferation, cytoarchitecture and cell size

González-Mariscal, L., Gallegos-Gutiérrez, H., González-González, L., and Hernández-Guzmán, C.
Int. J. Mol. Sci. (2019) 20:4128-4152.

Activation of the Ca2+ sensing receptor and the PKC/WNK4 downstream signaling cascade induces incorporation of ZO-2 to tight junctions and its separation from 14-3-3.

Amaya, E., Alarcón, L.,  Martín-Tapia, D.,  Cuellar-Pérez, F.,  Cano-Cortina, M., Ortega-Olvera, J. M., Cisneros, B.,  Rodriguez, A. J., Gamba, G.,  and González-Mariscal, L .
Mol. Biol. Cell (2019) 30:2377-2398.

The organophosphate pesticide methamidophos opens the blood-testis barrier and covalently binds to ZO-2 in mice

Ortega-Olvera, J. S., Winkler, R., Quitanilla-Vega, B., Shibayama, M., Chávez-Munguía, B., Martín-Tapia, D., Alarcón, L., and González-Mariscal, L.
Toxicology and Applied Pharmacology (2018) 360:257-272.

Dengue virus enters and exits epithelial cells through both apical and basolateral surfaces and perturbs the apical junctional complex

Ramírez, L., Betanzos, A., Raya, A., González-Mariscal, L., and del Angel R.M.
Virus Res. (2018) 258:39-41.

The calcium-sensing receptor increases activity of the renal NaCl cotransporter through the WNK4-SPAK pathway

Bazua-Valenti, S., Rojas-Vega, L., Castañeda-Bueno, M., Barrera-Chimal, J., Bautista, R., Cervantes-Pérez, L.G., Vázquez, N., Plata, C., González-Mariscal, L., Ellison, D.H., Riccardi, D., Bobadilla, N.A., and Gamba, G.
Journal of the American Society of Nephrology (JASN) (2018) 29:1838-1848.

Giardipain-1, a protease secreted by Giardia duodenalis trophozoites causes junctional, barrier and apoptotic damages in epithelial cell monolayers

Ortega-Pierres, G., Argüello-García, R., Laredo-Cisneros. M. S., Fonseca-Linán R., Gómez-Mondragón M., Inzunza-Arroyo, R., Flores-Benítez, D., Raya-Sandino, A., Chavez-Munguía, B., Ventura-Gallegos, J. L., Zentella-Dehesa, A., Bermúdez-Cruz, R. M., and González-Mariscal, L.
International Journal of Parasitology (2018) 48:621-639.

Relationship between G proteins coupled receptors and tight junctions

González-Mariscal, L., Raya-Sandino, A., González-González, A., and Hernández-Guzmán, C.
Tissue Barriers (2018) 6(1): e1414015.

Catsper1 promoter is bidirectional and regulates the expression of a novel lncRNA.

Jiménez-Badillo, S.E., Oviedo, N., Hernández-Guzmán, C., González-Mariscal, L., and Hernández-Sánchez, J.
Scientific Reports (2017) 7:13351.

Zonula occludens-2 regulates Rho proteins activity and the development of epithelial cytoarchitecture and barrier function

Raya-Sandino A., Castillo-Kauil A., Domínguez-Calderón A., Alarcón L., Flores-Benitez D., Cuellar-Perez F., López-Bayghen B., Chávez-Munguía B., Vázquez-Prado J., and González-Mariscal L.
Biochim Biophys Acta. Molecular Cell Research (2017) 1864:1714-1744

ZO-2, a tight junction protein involved in gene expression, proliferation, apoptosis and cell size regulation

González-Mariscal, L., Miranda, J., Raya-Sandino, A., Domínguez-Calderón, A. and Cuellar-Pérez, F.
Ann. N.Y. Acad. Sci. (2017) 1397:35-53

Perinatal administration of bisphenol A alters the expression of tight junction proteins in the uterus and reduces the implantation rate

Martínez-Peña A.A., Rivera-Baños J., Méndez-Carrillo, L. L., Ramírez-Solano M. I., Galindo-Bustamante A., Páez-Franco J. C., Morimoto S., González-Mariscal L., Cruz M. E., Mendoza-Rodríguez C. A.
Reproductive Toxicology, 69: 106-120, (2017).

SUMOylation regulates the intracellular fate of ZO-2

Wetzel, F., Mittag, S., Cano-Cortina, M., Wagner, T., Krämer H.O., Niedenthal, R., González-Mariscal, L., Huber, O.
Cell. Mol. Life Sci. 74:373-392, (2017).

GAS1 is presented in the cerebrospinal fluid and is expressed in the choroid plexus of the adult rat

Ayala-Sarmiento, AE., Estudillo, E., Pérez-Sánchez, G., Sierra-Sánchez, A., González-Mariscal, L., Martínez-Fong, D., Segovia, J.
Histochem. Cell. Biol. 146(3): 325-336, (2016)

Zonula occludens proteins in cancer

González-Mariscal, L.,  Miranda, J.,  Ortega-Olvera, J.M.,  Gallego-Gutiérrez, H., Raya-Sandino, A., and Vargas-Sierra, O.
Curr. Pathobiol. Rep. (4): 107-116,  (2016). (0 citas A y 1 cita B)

Involvement of tight junction plaque proteins in cancer

González-Mariscal, L.,  Miranda, J.,  Ortega-Olvera, J.M.,  Gallego-Gutiérrez, H., Raya-Sandino, A., and Vargas-Sierra, O.
Curr. Pathobiol. Rep. (4): 117-133 (2016).

Strategies that target tight junctions for enhanced drug delivery

González-Mariscal, L., Posadas-Torrentera, Y., Miranda, J., Uc, P., Ortega-Olvera, J.M., and Hernández, S.
Current Pharmaceutical Design. 22(35) 5313-5346 (2016).

ZO-2 silencing induces renal hypertrophy through a cell cycle mechanism and the activation of YAP and the mTOR pathway

Domínguez-Calderón, A., Avila-Flores, A., Ponce, A., López-Bayghen, E., Calderón-Salinas, J. V., Reyes, J. L., Chávez-Munguía, B., Segovia, J., Angulo, C., Ramírez, L., Gallego-Gutierrez, H., Alarcón, L., Martín-Tapia, D., Bautista-Garcia, P., and González-Mariscal, L.
Mol. Biol. Cell. 27(10): 1581-95 (2016).

Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways

Martínez-Revollar, G., Garay, E., Martin-Tapia, D., Nava, P., Huerta, M., Lopez-Bayghen, E., Meraz-Cruz, N., Segovia, J., and González-Mariscal, L.
Exp. Cell Res. 339:67-80 (2015).

CAPITULOS DE LIBROS

Intracellular traffic and non-canonical roles of ZO-2 protein” in “Tight Junctions”

González-Mariscal, L., Pinto-Dueñas, D. C., Hernández-Guzmán, C., Gallego-Gutiérrez, H., González-González, L., and Cano-Cortina, M. Chapter 4, pg 51-84. Ed. Lorenza González-Mariscal.
Springer, Switzerland (2022).

LIBROS

Tight Junctions

Editora Lorenza González-Mariscal. Pgs: 334.
Springer, Switzerland, 2022.

Estudiantes de Maestría

Pedro Guillermo Díaz Bautista

pedrog.diaz@cinvestav.mx

Anderson Javier Hernández Ramírez

anderson.hernandez@cinvestav.mx

Rubí Andrea León Martínez

rubi.leon@cinvestav.mx

Estudiantes de Doctorado

Mayrelis Fernández Hernández

mayrelis.fernandez@cinvestav.mx

Elio Armando Fontes Otero

elio.fontes@cinvestav.mx

Diego Lara Morales

diego.lara@cinvestav.mx

Erick Susano López

erick.susano@cinvestav.mx

Personal

María de Lourdes Alarcón Mortera

Auxiliar de Investigación

lalarcon@fisio.cinvestav.mx

Dolores Martín Tapia

Auxiliar de Investigación

dolores@fisio.cinvestav.mx

Miguel Angel Rojas Sierra

Auxiliar de Investigación

mrojas@fisio.cinvestav.mx